Data mining techniques are used to describe and predict the features from existing data set in the filed of Science, Medical, Engineering and Social science. The combination of neuroscience, Supercomputing and nano technologies is involved in the cognitive computing. But the design architecture involved the computational approach to increase the speed of computing while neurons are communicated one with another at a instance .The activation process based on the selection of neuron which are expected to activate in the instance of time. The activation based on the specific cluster .As a initial level of analysis,this work attempted to identify neuron activation process through cluster techniques to identify similar process neuron from the Magnetic Resonance Imaging (MRI) analysis. The cluster algorithm and generated frequency along with the obtained results are discussed as part of this paper.